My Mopar is still better than your Found On the Road Dead...
When it comes to CPU's I still stick to Intel for their reliability. The only servers we lost in our data room when the air went out over a weekend were the AMD's.
When it comes to the business environment as a support company we've replaced more AMD's with Intel's over the years because of hardware problems. We normally replace Intel's when the clients need to upgrade.
As for the home I wouldn't have a preference and have sold some AMD's (the Opterons) to clients that wanted a computer for the home. They perform well and you can save money buying them.
As to having problems with software running on the new CPU's either AMD or Intel that's a problem with the software and hardware companies problems, not the CPU's.
I just got the 64Bit drivers for my Spyder 2. I hadn't been able to use it since going to XP 64Bit. Everything else works just fine on mine.