One thing you have to consider is the magnification of the lens and the number of pixels that cover the eye area. I think what you want more than sharpness is detail. There are two ways to get that detail; more megapixels or fill the frame with the subject's face. Here's a couple of examples for you. The first is a 100% crop taken from a 22MP digital back using my Hasselblad H2 & 210mm f/4 lens:
Resized image showing the shot with a little crop:
Now a 100% crop of the eyes from the full size tiff:
Contrast those two samples with a shot from my 12.1MP D3 and the 70-200mm f/2.8:
Resized image for web portfolio:
100% crop from the full size tiff:
See the difference. When the eyes get more pixels either by magnification or sensor MP count, you get more details. Sharpness is really more of an edge definition which can make images look 'fake' when taken too far.
Make sense?