I am not our uploading guru, but that is not a typical response. Usually out of the many many uploaders we provide, most work extremely well.
Make sure you have an internet connection, that is the first thing. Then go and try our "Simple" uploader to make sure it works. (The reason I say that is because it is our easiest and most reliable.)
Send To SmugMug is extremely reliable as well, but it was created by a Microsoft employee and so we don't necessarily troubleshoot it.
However, Omar is really good about answering his emails if you have questions on it.
NOTE: we do have integration to PSE6 if you want to upload directly from that application. Follow this tutorial:
http://wiki.smugmug.net/display/Smug...ts+6+Uploading
If none of this works, please email our help desk and they will respond immediately. Help at smugmug dot com